Effect of clindamycin on pneumonia from reactivation of Toxoplasma gondii infection in mice.

نویسندگان

  • G A Filice
  • C Pomeroy
چکیده

Clindamycin was used to treat the reactivation of a chronic Toxoplasma gondii infection in mice. Clindamycin reduced mortality by 44% when used prophylactically (P less than 0.001) but appeared to be less effective when used to treat clinically apparent reactivation. Further studies should be conducted to establish the efficacy of clindamycin for the treatment of toxoplasmosis in humans.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Inhibitory effects of Clindamycin on shedding of Toxoplasma gondii oocyst and its comparison with Monensin in kitten

  The efficacy of Clindamycin and Monensin were evaluated in the prevention of oocyst shedding of kittens with Toxoplasma gondii (Tehran strain). In this study, 28 healthy kittens aged 1.5 – 2 months old divided randomly into 4 groups of seven. In group 1, Kittens were fed with the infected brain tissues of mice, all of seven kittens (100 %), shed oocyst, nearly 1 week after infection, which la...

متن کامل

Changes in cytokine levels during reactivation of Toxoplasma gondii infection in lungs.

We studied cytokine proteins and mRNAs in mice with two forms of Toxoplasma gondii pneumonia resulting from reactivation of infection. In the first form, mice were infected with T. gondii, developed and recovered from systemic disease, and then developed pneumonia 3 weeks later. As pulmonary inflammation developed, levels of cytokine mRNAs for gamma interferon (IFN-gamma), interleukin-2 (IL-2),...

متن کامل

P-146: Toxoplasmosis: Experimental Vaginal Infection in NMRI Mice and Effect on Uterin,Placenta and Fetus Tissues

Background: Toxoplasma gondii is an important zoonotic pathogen. Vertical transmission of the parasite occurs when females were infected primarily during gestation. This parasite transmitted to the fetus through the placenta and may cause miscarriage, permanent neurological damage, premature birth and visual impairment. Materials and Methods: Two 6-8-week NMRI females mice were crossed with one...

متن کامل

Study of resistance to Toxoplasmosis using Tachizoites surface antigens of Toxoplasma gondii in vivo

Taoxoplasma gondii is an important food-borne parasite transmitted primarily from animals to humans through meat consumption, mainly pork and lamb, as well as through oocysts shed by cats. Infection in humans can cause severe fetal malformations, ocular complications or encephalitis. Toxoplasmosis infection during pregnancy, especially in sheep, often results in abortion, representing considera...

متن کامل

Immunogenicity of Gamma-Irradiated Toxoplasma gondii Tachyzoites in Mice

The Immunogenicity of γ-irradiated tachyzoites of a highly virulent strain of Toxoplasma gondii (RH strain) was investigated. Immunized mice survived challenge infection and displayed increased interferon gamma (INF-γ ) production. On the other hand, nonimmunized controls died after 10 days and displayed a significantly decreased lymphoproliferative response to Concanavalin A (Con A). No tachyz...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 35 4  شماره 

صفحات  -

تاریخ انتشار 1991